Scientific Evidence: Beta-caryophyllene is a natural terpene that exists in the cannabis and hemp plants as well as in other common plants (eg. Cloves and black pepper). It is known to work directly on cannabinoid CB2 receptors to help decrease inflammation synergistically with cannabinoids such as THC and CBD (sometimes described as the “entourage” effect). known to have effects at the molecular level to help control pain through cannabinoid receptors (CB1 and CB2) in the body.
Clinical and Scientific Evidence References:
Sari Goldstein Ferber,1,3 Dvora Namdar,2 Danielle Hen-Shoval,1,3 Gilad Eger,4,5 Hinanit Koltai,2 Gal Shoval,4,5,* Liat Shbiro,4 and Aron Weller1,The “Entourage Effect”: Terpenes Coupled with Cannabinoids for the Treatment of Mood Disorders and Anxiety Disorders, Curr Neuropharmacol. 2020 Feb; 18(2): 87–96.
Scandiffio R et al. Protective Effects of (E)–Caryophyllene (BCP) in Chronic Inflammation. Nutrients 2020, 12, 3273.
Scientific Evidence: Beta-caryophyllene (BCP) is a natural terpene that exists in the cannabis and hemp plants as well as in other common plants (eg. cloves and black pepper). It is a known CB2 receptor agonist and therefore can modulate inflammation synergistically with cannabinoids such as THC and CBD (sometimes described as the “entourage” effect). Animal data also suggests that BCP may produce an anti-anxiety effect via activation of CB2 receptor activation.
Amine, Bahia1, Shamma Al Mansouria Elyazia Al Memaria , Mouza Al Ameria , Syed MNurulainb, ShreeshOjhab1, β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice, Physiology & Behavior
Volume 135, August 2014, Pages 119-124