Our CB4™ brand of medical cannabis products are based on science and engineered to deliver results.

CB4 Relief Extra Strength (4x) Daytime Softgels (THC Free)

25mg CBD Softgel Capsules


CBD 25 mg/softgel
THC 0 mg/softgel
BCP 13 mg/softgel

High potency, fast acting, long lasting: This non-drowsy THC-free formula can be used during day or in the evening. Has 4x higher potency (based on peak absorption) and 3x faster onset (faster time to reach peak) versus most other oral CBD products. See below for graphs and clinical data.

Opticann’s CB4 Relief are convenient amber-coloured softgel capsules, providing medical patients with the highest potency, rapid-acting oral CBD option. Especially formulated and clinically tested to deliver maximum levels of phytocannabinoids per softgel: 25mg of CBD and 13mg of Beta-Caryophyllene (BCP), two ingredients known to have activity on cannabinoid receptors, and VESIsorb® technology. VESIsorb® is used to maintain the quality and stability of the product.

Contains no THC to limit unwanted side effects. Gluten-free, non-GMO formulation.

One CB4 Relief equals 4 other CBD capsules in potency

Size Price
15 Caps $45.99
30 Caps $89.99

Scientific Evidence:
CBD Evidence for Pain and Inflammation
CBD Evidence for Anxiety and PTSD
BCP Evidence for Inflammation
VESIsorb® Evidence for Rapid and Maximum CBD Absorption
VESIsorb® Evidence for Rapid and Maximum BCP Absorption

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CB4 Relief is formulated with VESIsorb®, a safe and effective water-soluble patented drug delivery pharmaceutical technology that can help dramatically improve the bioavailability of poorly absorbed ingredients such as CBD and terpenes, such as beta-caryophyllene.

A clinical trial with VESIsorb® products tested for improvement in CBD absorption showed a 4.4-fold increase in peak absorption (Cmax) and reached 3x faster plasma concentration (Tmax) than comparable CBD products without VESIsorb®1.

CBD Performance Advantage (25 mg) CB4 Relief Normal CBD in MCT Oil CB4 Advantage
CBD Cmax (Maximum concentration) -effect 13 ng/mL 3 ng/mL 4.4x more
CBD Tmax (Time to reach maximum concentration) -onset of action 1 hour 3 hours 3x faster

There are peer-reviewed published clinical studies that show orally administered ingredients are absorbed faster and to a greater extent with VESIsorb® than products without.2

BCP Performance Advantage (100 mg) CB4 Relief Normal CBD in MCT Oil CB4 Advantage
BCP Cmax (Maximum concentration) -effect 205 ng/mL 58 ng/mL 3.6x more
BCP Tmax (Time to reach maximum concentration) -onset of action 1.4 hours 3.1 hours 2x faster


1 Knaub K, et al. “A Novel Self-Emulsifying Drug Delivery System (SEDDS) Based on VESIsorb® Formulation Technology Improving the Oral Bioavailability of Cannabidiol in Healthy Subjects.” Molecules, vol.24, no.2964, Aug 2019
2 Modinger, Yvonne, et al. “Enhanced Oral Bioavailability of β-Caryophyllene in Healthy Subjects Using the VESIsorb® Formulation Technology, a Novel Self-Emulsifying Drug Delivery System (SEDDS).” Molecules, vol.27(9), no.2860, May 2022


Each softgel contains: Cannabis Sativa Extract 25 mg CBD, 13 mg Beta-Caryophyllene, Vitamin E Dimer Derivative, Mono and Diglycerides, Fatty Acids, Natural Flavours, Gelatin (Bovine), Glycerine, Carob, Water.

The product image and label are provided for illustrative purposes only. Actual labels may vary.

Potency per bottle

15 capsule bottle contains: 30 capsule bottle contains:
CBD 375 mg CBD 750 mg

How to Use

Directions: Take one softgel daily, with or without food. The higher absorption from CB4 Relief softgels may enable patients to take one dose once or up to twice daily. For best efficacy, take medications at the same time every day. Store CBD softgels in a cool, dry place, away from direct sunlight.

Patients with known hypersensitivities to oral CBD should exercise caution when consuming this product.

Talk to your healthcare provider (physician or pharmacist) about what dose is right for you. Your healthcare provider can advise you on drug interactions, precautions, and contraindications

cbd capsules Benefits of oral capsules

  • Consistent and long-lasting effect
  • Avoids the byproducts of inhalants
  • Portable and easy-to-swallow
  • Standardized, precision dosage