Description
CB4 Relief is formulated with VESIsorb®, a safe and effective water-soluble patented drug delivery pharmaceutical technology that can help dramatically improve the bioavailability of poorly absorbed ingredients such as CBD and terpenes, such as beta-caryophyllene.
A clinical trial with VESIsorb® products tested for improvement in CBD absorption showed a 4.4-fold increase in peak absorption (Cmax) and reached 3x faster plasma concentration (Tmax) than comparable CBD products without VESIsorb®1.
| CBD Performance Advantage (25 mg) | CB4 Relief | Normal CBD in MCT Oil | CB4 Advantage |
| CBD Cmax (Maximum concentration) -effect | 13 ng/mL | 3 ng/mL | 4.4x more |
| CBD Tmax (Time to reach maximum concentration) -onset of action | 1 hour | 3 hours | 3x faster |
There are peer-reviewed published clinical studies that show orally administered ingredients are absorbed faster and to a greater extent with VESIsorb® than products without.2
| BCP Performance Advantage (100 mg) | CB4 Relief | Normal CBD in MCT Oil | CB4 Advantage |
| BCP Cmax (Maximum concentration) -effect | 205 ng/mL | 58 ng/mL | 3.6x more |
| BCP Tmax (Time to reach maximum concentration) -onset of action | 1.4 hours | 3.1 hours | 2x faster |
References:
1 Knaub K, et al. “A Novel Self-Emulsifying Drug Delivery System (SEDDS) Based on VESIsorb® Formulation Technology Improving the Oral Bioavailability of Cannabidiol in Healthy Subjects.” Molecules, vol.24, no.2964, Aug 2019
2 Modinger, Yvonne, et al. “Enhanced Oral Bioavailability of β-Caryophyllene in Healthy Subjects Using the VESIsorb® Formulation Technology, a Novel Self-Emulsifying Drug Delivery System (SEDDS).” Molecules, vol.27(9), no.2860, May 2022
Benefits of oral capsules